Translation initiation factor 4E in complex with M7G(5'S)PPP(5'S)G mRNA 5' cap analog

Structure

x-ray diffraction · 3 distinct chains.

Ligands and binding sites

• AKW · [(2~{S},3~{S},4~{R},5~{R})-5-(2-azanyl-7-methyl-6-oxidanylidene-3~{H}-purin-7-ium-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanyl-[[[(3~{R}, 4~{S})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanyl-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-phosphinic acid · ligand · 2 copies · chains A, B
• K · Potassium ion · metal · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 5OSX · Translation initiation factor 4E in complex with m7G(5'S)ppp(5'S)G mRNA 5' cap analog · the same entry in another collection · chain A against A, TM-score 1.00
• P63073 · AlphaFold monomer V2.0 prediction for eukaryotic translation initiation factor 4E (P63073) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P63073
• Elsewhere: RCSB PDB 5OSX · PDBe 5OSX · UniProt P63073