MolNFT v1 · #129270 · protein
Crystal structure of human MORC2 (residues 1-603)
5OF9 · Morc family cw-type zinc finger protein 2: “Crystal structure of human MORC2 (residues 1-603)”. X-ray diffraction, 3 ligands (ANP, ZN, MG), 11 pockets (best druggability 0.75). MolNFT v1 #129270 on GenesisL1: 3D structure, binding…
- PDB
- 5OF9
- Type
- protein
- Length
- 1,074 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Morc family cw-type zinc finger protein 2
- UniProt
- Q9Y6X9
- Ligands
- ANP, ZN, MG
- Pockets
- 11 · best druggability 0.75
Structure
x-ray diffraction · 2 distinct chains · 37% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Morc family cw-type zinc finger protein 2 | protein | 536 | 37% helix, 22% strand | Q9Y6X9 |
| B | Morc family cw-type zinc finger protein 2 | protein | 538 | 37% helix, 21% strand | Q9Y6X9 |
Ligands and binding sites
- ANP · Phosphoaminophosphonic acid-adenylate ester · ligand · 2 copies · chains A, B
- ZN · Zinc ion · metal · 2 copies · chains A, B
- MG · Magnesium ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
11 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 465 | 0.75 | 0.84 | 59 | empty |
| 2 | 306 | 0.74 | 0.86 | 40 | ANP, MG |
| 3 | 324 | 0.73 | 0.85 | 40 | ANP, MG |
| 4 | 295 | 0.71 | 0.85 | 48 | empty |
| 5 | 634 | 0.68 | 0.76 | 48 | empty |
Interfaces
1 interface between chains.
- A–B · 2961 Ų buried · 51 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9Y6X9
- Elsewhere: RCSB PDB 5OF9 · PDBe 5OF9 · UniProt Q9Y6X9
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.