MolNFT v1 · #128583 · protein
Structure of human transforming growth factor beta-induced protein (tgfbip).
5NV6 · Transforming growth factor-beta-induced protein ig-H3: “Structure of human transforming growth factor beta-induced protein (tgfbip).”. X-ray diffraction, 16 pockets (best druggability 0.67). MolNFT v1 #128583 on GenesisL1: 3D…
- PDB
- 5NV6
- Type
- protein
- Length
- 1,184 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transforming growth factor-beta-induced protein ig-H3
- UniProt
- Q15582
- Pockets
- 16 · best druggability 0.67
Structure
x-ray diffraction · 2 distinct chains · 31% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transforming growth factor-beta-induced protein ig-H3 | protein | 595 | 31% helix, 29% strand | Q15582 |
| B | Transforming growth factor-beta-induced protein ig-H3 | protein | 589 | 32% helix, 29% strand | Q15582 |
Ligands and binding sites
- ACT · Acetate ion · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
16 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 416 | 0.67 | 0.80 | 44 | empty |
| 2 | 389 | 0.66 | 0.80 | 41 | empty |
| 3 | 492 | 0.63 | 0.76 | 61 | empty |
| 4 | 351 | 0.61 | 0.78 | 53 | empty |
| 5 | 253 | 0.52 | 0.75 | 36 | empty |
Interfaces
1 interface between chains.
- A–B · 452 Ų buried · 4 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 10 disulfide (disulfide).
Compared structures
- 5NV6 · Structure of human transforming growth factor beta-induced protein (TGFBIp). · the same entry in another collection · chain A against A, TM-score 1.00
- Q15582 · AlphaFold monomer V2.0 prediction for transforming growth factor- beta-induced protein… · a predicted model of the same protein · chain B against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q15582
- Elsewhere: RCSB PDB 5NV6 · PDBe 5NV6 · UniProt Q15582
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