MolNFT v1 · #128266 · protein
Crystal structure of human CUL3 N-terminal domain bound to KEAP1 btb and 3-box
5NLB · Kelch-like ech-associated protein 1: “Crystal structure of human CUL3 N-terminal domain bound to KEAP1 btb and 3-box”. X-ray diffraction, 3 pockets (best druggability 0.68). MolNFT v1 #128266 on GenesisL1: 3D structure, binding…
- PDB
- 5NLB
- Type
- protein
- Length
- 502 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Kelch-like ech-associated protein 1; Cullin-3
- UniProt
- Q14145, Q13618
- Pockets
- 3 · best druggability 0.68
Structure
x-ray diffraction · 2 distinct chains · 71% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Kelch-like ech-associated protein 1 | protein | 154 | 49% helix, 8% strand | Q14145 |
| B | Cullin-3 | protein | 348 | 81% helix, 0% strand | Q13618 |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 172 | 0.68 | 0.87 | 37 | empty |
| 2 | 286 | 0.60 | 0.78 | 37 | empty |
| 3 | 85 | 0.48 | 0.82 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 864 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q14145
- Every structure of UniProt Q13618
- Elsewhere: RCSB PDB 5NLB · PDBe 5NLB · UniProt Q14145 · UniProt Q13618
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