MolNFT v1 · #128079 · protein

The structure of the polo-box domain (pbd) of polo-like kinase 1 (PLK1) in complex with lhspta peptide.

5NFU · SERINE/THREONINE-protein kinase PLK1: “The structure of the polo-box domain (pbd) of polo-like kinase 1 (PLK1) in complex with lhspta peptide.”. X-ray diffraction, 1 pocket (best druggability 0.43). MolNFT v1 #128079 on GenesisL1…

PDB: 5NFU
Type: protein
Length: 228 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: SERINE/THREONINE-protein kinase PLK1; Ac-leu-his-ser-(tpo)-ala
EC: 2.7.11.21
UniProt: P53350
Pockets: 1 · best druggability 0.43

Structure

x-ray diffraction · 2 distinct chains · 30% helix, 29% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	SERINE/THREONINE-protein kinase PLK1 (EC 2.7.11.21)	protein	223	31% helix, 29% strand	P53350
C	Ac-leu-his-ser-(tpo)-ala	protein	5	0% helix, 0% strand	—

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	148	0.43	0.75	30	empty

Interfaces

1 interface between chains.

A–C · 462 Å² buried · 11 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 modified (nonstandard, phosphorylation).

Compared structures

5NFU · The structure of the polo-box domain (PBD) of polo-like kinase 1 (Plk1) in complex with… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P53350
Elsewhere: RCSB PDB 5NFU · PDBe 5NFU · UniProt P53350

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