MolNFT v1 · #127790 · protein

Microtubule end binding protein complex

5N74 · Microtubule-associated protein RP/EB family member 1: “Microtubule end binding protein complex”. X-ray diffraction, 5 pockets (best druggability 0.71). MolNFT v1 #127790 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5N74
Type: protein
Length: 529 residues
Chains: 16
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Microtubule-associated protein RP/EB family member 1; Karyogamy protein KAR9
UniProt: Q15691, P32526
Pockets: 5 · best druggability 0.71

Structure

x-ray diffraction · 10 distinct chains · 65% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, C, D, G	Microtubule-associated protein RP/EB family member 1	protein	55	85% helix, 0% strand	Q15691
B, H	Microtubule-associated protein RP/EB family member 1	protein	56	84% helix, 0% strand	Q15691
E	Microtubule-associated protein RP/EB family member 1	protein	54	87% helix, 0% strand	Q15691
F	Microtubule-associated protein RP/EB family member 1	protein	53	81% helix, 0% strand	Q15691
I	Karyogamy protein KAR9	protein	7	0% helix, 0% strand	P32526
J, M	Karyogamy protein KAR9	protein	13	0% helix, 0% strand	P32526
K, N	Karyogamy protein KAR9	protein	12	0% helix, 0% strand	P32526
L	Karyogamy protein KAR9	protein	10	0% helix, 0% strand	P32526
O	Karyogamy protein KAR9	protein	12	0% helix, 0% strand	P32526
P	Karyogamy protein KAR9	protein	11	0% helix, 0% strand	P32526

Pockets

5 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	867	0.71	0.76	58	empty
2	756	0.67	0.75	50	empty
3	231	0.57	0.79	34	empty
4	139	0.51	0.80	29	empty
5	57	0.34	0.77	15	empty

Interfaces

38 interfaces between chains.

A–B · 1505 Å² buried · 13 hydrogen bonds · protein-protein
C–D · 1504 Å² buried · 8 hydrogen bonds · protein-protein
G–H · 1459 Å² buried · 9 hydrogen bonds · protein-protein
E–F · 1445 Å² buried · 10 hydrogen bonds · protein-protein
H–O · 465 Å² buried · 7 hydrogen bonds · protein-protein

Compared structures

5N74 · Microtubule end binding protein complex · the same entry in another collection · chain P against P, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q15691
Every structure of UniProt P32526
Elsewhere: RCSB PDB 5N74 · PDBe 5N74 · UniProt Q15691 · UniProt P32526

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