MolNFT v1 · #127723 · protein

Crystal structure of human pim-1 kinase in complex with a consensus peptide and fragment like molecule 2-(4-chlorophenyl) sulfanylacetohydrazide

5N50 · SERINE/THREONINE-protein kinase pim-1: “Crystal structure of human pim-1 kinase in complex with a consensus peptide and fragment like molecule…”. X-ray diffraction, 1 ligand (8MN), 1 pocket (best druggability 0.72). MolNFT v1…

PDB: 5N50
Type: protein
Length: 282 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: SERINE/THREONINE-protein kinase pim-1; Pimtide
EC: 2.7.11.1
UniProt: P11309
Ligands: 8MN
Pockets: 1 · best druggability 0.72

Structure

x-ray diffraction · 2 distinct chains · 39% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	SERINE/THREONINE-protein kinase pim-1 (EC 2.7.11.1)	protein	273	40% helix, 23% strand	P11309
B	Pimtide	protein	9	0% helix, 0% strand	—

Ligands and binding sites

8MN · 2-(4-chlorophenyl)sulfanylethanehydrazide · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	421	0.72	0.82	51	8MN

Interfaces

1 interface between chains.

A–B · 592 Å² buried · 15 hydrogen bonds · protein-protein

Compared structures

5N50 · Crystal structure of human Pim-1 kinase in complex with a consensus peptide and fragment… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P11309
Elsewhere: RCSB PDB 5N50 · PDBe 5N50 · UniProt P11309

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