MolNFT v1 · #127539 · protein
Udp-glucose glycoprotein glucosyltransferase from chaetomium thermophilum (open conformation)
5MZO · Udp-glucose-glycoprotein glucosyltransferase-like protein: “Udp-glucose glycoprotein glucosyltransferase from chaetomium thermophilum (open conformation)”. X-ray diffraction, 4 ligands (NAG, MAN, BMA), 19 pockets (best druggability…
- PDB
- 5MZO
- Type
- protein
- Length
- 1,373 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Udp-glucose-glycoprotein glucosyltransferase-like protein
- UniProt
- G0SB58
- Ligands
- NAG, MAN, BMA, CA
- Pockets
- 19 · best druggability 0.80
Structure
x-ray diffraction · 1 distinct chain · 38% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Udp-glucose-glycoprotein glucosyltransferase-like protein | protein | 1373 | 38% helix, 18% strand | G0SB58 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 9 copies · chains A
- MAN · alpha-D-mannopyranose · sugar · 2 copies
- BMA · beta-D-mannopyranose · sugar
- CA · Calcium ion · metal · chains A
- EDO · 1,2-ethanediol · additive · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
19 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 772 | 0.80 | 0.83 | 75 | EDO |
| 2 | 778 | 0.78 | 0.82 | 76 | empty |
| 3 | 766 | 0.76 | 0.81 | 68 | empty |
| 4 | 305 | 0.69 | 0.83 | 36 | empty |
| 5 | 144 | 0.58 | 0.83 | 23 | empty |
Modifications
Observed in the structure: 5 glycan, 3 disulfide (N-glycosylation, disulfide).
Compared structures
- 5MZO · UDP-Glucose Glycoprotein Glucosyltransferase from Chaetomium thermophilum (open… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G0SB58
- Elsewhere: RCSB PDB 5MZO · PDBe 5MZO · UniProt G0SB58
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