Complex between the leucine zipper (lz, residues 490-567) and centrosomin-motif 2 (CM2) domains of drosophila melanogaster centrosomin (cnn)

Structure

x-ray diffraction · 3 distinct chains · 92% helix, 0% strand (DSSP).

Ligands and binding sites

• TCE · 3,3',3''-phosphanetriyltripropanoic acid · ligand · chains A, C, B
• ZN · Zinc ion · metal · chains A, B
• EDO · 1,2-ethanediol · additive · 2 copies · chains A, C, D, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Interfaces

6 interfaces between chains.

• A–B · 892 Ų buried · 9 hydrogen bonds · protein-protein
• C–D · 493 Ų buried · 0 hydrogen bonds · protein-protein
• A–D · 390 Ų buried · 0 hydrogen bonds · protein-protein
• C–B · 386 Ų buried · 0 hydrogen bonds · protein-protein
• A–C · 380 Ų buried · 5 hydrogen bonds · protein-protein

Compared structures

• 5MWE · Complex between the Leucine Zipper (LZ, residues 490-567) and Centrosomin-motif 2 (CM2)… · the same entry in another collection · chain B against B, TM-score 1.00
• P54623 · AlphaFold monomer V2.0 prediction for centrosomin (P54623) · a predicted model of the same protein · chain A against A, TM-score 0.88

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P54623
• Elsewhere: RCSB PDB 5MWE · PDBe 5MWE · UniProt P54623