MolNFT v1 · #127392 · protein
Structure of human myosin 7B C-terminal MYTH4-ferm domain in complex with harmonin-a PDZ3 domain
5MV8 · Unconventional myosin-viib: “Structure of human myosin 7B C-terminal MYTH4-ferm domain in complex with harmonin-a PDZ3 domain”. X-ray diffraction, 1 ligand (MG), 7 pockets (best druggability 0.60). MolNFT v1 #127392 on GenesisL1: 3D…
- PDB
- 5MV8
- Type
- protein
- Length
- 599 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Unconventional myosin-viib; Cdna FLJ51329, highly similar to harmonin
- UniProt
- Q6PIF6, B4DV53
- Ligands
- MG
- Pockets
- 7 · best druggability 0.60
Structure
x-ray diffraction · 2 distinct chains · 38% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Unconventional myosin-viib | protein | 479 | 44% helix, 15% strand | Q6PIF6 |
| B | Cdna FLJ51329, highly similar to harmonin | protein | 120 | 17% helix, 28% strand | B4DV53 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 266 | 0.60 | 0.79 | 47 | empty |
| 2 | 129 | 0.48 | 0.78 | 14 | GOL |
| 3 | 100 | 0.46 | 0.79 | 17 | empty |
| 4 | 79 | 0.46 | 0.81 | 18 | empty |
| 5 | 157 | 0.44 | 0.76 | 28 | empty |
Interfaces
1 interface between chains.
- A–B · 1319 Ų buried · 15 hydrogen bonds · protein-protein
Compared structures
- 5MV8 · Structure of human Myosin 7b C-terminal MyTH4-FERM domain in complex with harmonin-a PDZ3… · the same entry in another collection · chain A against A, TM-score 1.00
- Q6PIF6 · AlphaFold monomer V2.0 prediction for unconventional myosin-viib (Q6PIF6) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6PIF6
- Every structure of UniProt B4DV53
- Elsewhere: RCSB PDB 5MV8 · PDBe 5MV8 · UniProt Q6PIF6 · UniProt B4DV53
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