MolNFT v1 · #127391 · protein
Structure of human myosin 7B C-terminal MYTH4-ferm MF2 domain
5MV7 · Unconventional myosin-viib: “Structure of human myosin 7B C-terminal MYTH4-ferm MF2 domain”. X-ray diffraction, 2 ligands (TAM, SO4), 6 pockets (best druggability 0.62). MolNFT v1 #127391 on GenesisL1: 3D structure, binding sites…
- PDB
- 5MV7
- Type
- protein
- Length
- 493 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Unconventional myosin-viib
- UniProt
- Q6PIF6
- Ligands
- TAM, SO4
- Pockets
- 6 · best druggability 0.62
Structure
x-ray diffraction · 1 distinct chain · 43% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Unconventional myosin-viib | protein | 493 | 43% helix, 15% strand | Q6PIF6 |
Ligands and binding sites
- TAM · Tris(hydroxyethyl)aminomethane · ligand · 2 copies · chains A
- SO4 · Sulfate ion · ion · 3 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 299 | 0.62 | 0.79 | 30 | empty |
| 2 | 322 | 0.57 | 0.76 | 42 | empty |
| 3 | 161 | 0.51 | 0.79 | 23 | SO4 |
| 4 | 112 | 0.47 | 0.79 | 23 | empty |
| 5 | 79 | 0.33 | 0.74 | 17 | empty |
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6PIF6
- Elsewhere: RCSB PDB 5MV7 · PDBe 5MV7 · UniProt Q6PIF6
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.