MolNFT v1 · #127336 · protein
N-terminal domain of the human tumor suppressor ING5 C19S mutant
5MTO · Inhibitor of growth protein 5: “N-terminal domain of the human tumor suppressor ING5 C19S mutant”. X-ray diffraction, 2 ligands (NA, SO4), 3 pockets (best druggability 0.52). MolNFT v1 #127336 on GenesisL1: 3D structure, binding…
- PDB
- 5MTO
- Type
- protein
- Length
- 214 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Inhibitor of growth protein 5
- UniProt
- Q8WYH8
- Ligands
- NA, SO4
- Pockets
- 3 · best druggability 0.52
Structure
x-ray diffraction · 1 distinct chain · 87% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Inhibitor of growth protein 5 | protein | 107 | 87% helix, 0% strand | Q8WYH8 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 119 | 0.52 | 0.81 | 17 | empty |
| 2 | 71 | 0.37 | 0.78 | 12 | empty |
| 3 | 56 | 0.28 | 0.74 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 877 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 5MTO · N-terminal domain of the human tumor suppressor ING5 C19S mutant · the same entry in another collection · chain A against A, TM-score 1.00
- Q8WYH8 · AlphaFold monomer V2.0 prediction for inhibitor of growth protein 5 (Q8WYH8) · a predicted model of the same protein · chain A against A, TM-score 0.72
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8WYH8
- Elsewhere: RCSB PDB 5MTO · PDBe 5MTO · UniProt Q8WYH8
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