MolNFT v1 · #127172 · protein
Crystal structure of PCNA encoding the hypomorphic mutation S228I
5MOM · Proliferating cell nuclear antigen: “Crystal structure of PCNA encoding the hypomorphic mutation S228I”. X-ray diffraction, 5 pockets (best druggability 0.40). MolNFT v1 #127172 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 5MOM
- Type
- protein
- Length
- 748 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Proliferating cell nuclear antigen
- UniProt
- P12004
- Pockets
- 5 · best druggability 0.40
Structure
x-ray diffraction · 3 distinct chains · 19% helix, 47% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Proliferating cell nuclear antigen | protein | 251 | 19% helix, 47% strand | P12004 |
| B | Proliferating cell nuclear antigen | protein | 249 | 18% helix, 47% strand | P12004 |
| C | Proliferating cell nuclear antigen | protein | 248 | 19% helix, 48% strand | P12004 |
Pockets
5 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 127 | 0.40 | 0.75 | 20 | empty |
| 2 | 87 | 0.37 | 0.76 | 16 | empty |
| 3 | 61 | 0.32 | 0.76 | 16 | empty |
| 4 | 63 | 0.31 | 0.75 | 18 | empty |
| 5 | 62 | 0.29 | 0.74 | 17 | empty |
Interfaces
3 interfaces between chains.
- A–C · 700 Ų buried · 12 hydrogen bonds · protein-protein
- B–C · 683 Ų buried · 11 hydrogen bonds · protein-protein
- A–B · 676 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 5MOM · Crystal Structure of PCNA encoding the hypomorphic mutation S228I · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P12004
- Elsewhere: RCSB PDB 5MOM · PDBe 5MOM · UniProt P12004
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