MolNFT v1 · #126985 · protein
Kinase domain of human EPHB1 bound to a quinazoline-based inhibitor
5MJA: “Kinase domain of human EPHB1 bound to a quinazoline-based inhibitor”. X-ray diffraction, 2 ligands (7O3, SO4). MolNFT v1 #126985 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5MJA
- Type
- protein
- Length
- 549 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P54762
- Ligands
- 7O3, SO4
Structure
x-ray diffraction · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 273 | — | P54762 |
| B | — | protein | 276 | — | P54762 |
Ligands and binding sites
- 7O3 · 2-chloranyl-~{N}-[4-[(2-chloranyl-5-oxidanyl-phenyl) amino]quinazolin-7-yl]ethanamide · ligand · 2 copies · chains A, B
- SO4 · Sulfate ion · ion · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 5MJA · Kinase domain of human EphB1 bound to a quinazoline-based inhibitor · the same entry in another collection · chain A against A, TM-score 1.00
- P54762 · AlphaFold monomer V2.0 prediction for ephrin type-B receptor 1 (P54762) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P54762
- Elsewhere: RCSB PDB 5MJA · PDBe 5MJA · UniProt P54762
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