UniProt P54762
Ephrin type-B receptor 1 (P54762)
Ephrin type-B receptor 1 (UniProt P54762), EC 2.7.10.1: 13 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 3 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P54762
- Protein
- Ephrin type-B receptor 1
- EC
- 2.7.10.1
- Experimental structures
- 13
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 3 · 2 records with a druggable one
Structures
14 records of P54762 in the MolNFT archive: 13 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2DJS | Solution structures of the fn3 domain of human ephrin type-B receptor 1 | solution nmr | A | — | — |
| 2DJS | Solution structures of the FN3 domain of human ephrin type-B receptor 1 | solution nmr | A | — | — |
| 2EAO | Solution structure of the C-terminal SAM-domain of mouse ephrin type-B receptor 1 precursor (EC… | solution nmr | A | — | — |
| 2EAO | Solution structure of the C-terminal SAM-domain of mouse ephrin type-B receptor 1 precursor (ec… | solution nmr | A | — | — |
| 3ZFX | Crystal structure of EphB1 | x-ray diffraction | A, B, C, D, E, F, G, H, I | — | — |
| 3ZFX | Crystal structure of EPHB1 | x-ray diffraction | A, B, C, D, E, F, G, H, I | — | — |
| 5MJA | Kinase domain of human EPHB1 bound to a quinazoline-based inhibitor | x-ray diffraction | A, B | 7O3, SO4 | — |
| 5MJB | Kinase domain of human EPHB1, G703C mutant, covalently bound to a quinazoline-based inhibitor | x-ray diffraction | A, B | 7O3, SO4 | — |
| 6UMW | Crystal structure of hEphB1 bound with chlortetracycline | x-ray diffraction | A | CTC | 2 (best 0.63) |
| 6UMW | Crystal structure of HEPHB1 bound with chlortetracycline | x-ray diffraction | A | CTC | — |
| 7KPL | Crystal structure of HEPHB1 in apo form | x-ray diffraction | A | — | — |
| 7KPM | Crystal structure of hEphB1 bound with ADP | x-ray diffraction | A | ADP | 1 (best 0.58) |
| 7KPM | Crystal structure of HEPHB1 bound with ADP | x-ray diffraction | A | ADP | — |
| P54762 | AlphaFold monomer V2.0 prediction for ephrin type-B receptor 1 (P54762) | predicted | A | — | — |
Ligands
Experiment against prediction
- 7KPM chain A against the predicted model P54762: TM-score 0.98, RMSD 0.85 Å
- 7KPM chain A against the predicted model P54762: TM-score 0.98, RMSD 0.85 Å
- 6UMW chain A against the predicted model P54762: TM-score 0.98, RMSD 0.89 Å
- 6UMW chain A against the predicted model P54762: TM-score 0.98, RMSD 0.89 Å
- 7KPL chain A against the predicted model P54762: TM-score 0.98, RMSD 0.93 Å
- 3ZFX chain C against the predicted model P54762: TM-score 0.97, RMSD 1.05 Å
- 3ZFX chain C against the predicted model P54762: TM-score 0.97, RMSD 1.05 Å
- 3ZFX chain B against the predicted model P54762: TM-score 0.97, RMSD 1.03 Å
- 3ZFX chain B against the predicted model P54762: TM-score 0.97, RMSD 1.03 Å
- 3ZFX chain G against the predicted model P54762: TM-score 0.97, RMSD 1.03 Å
Elsewhere
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