MolNFT v1 · #126881 · protein + DNA
New insights into the role of DNA shape on its recognition by P53 proteins (complex P53DBD-P53R2)
5MG7 · Cellular tumor antigen P53: “New insights into the role of DNA shape on its recognition by P53 proteins (complex P53DBD-P53R2)”. X-ray diffraction, 1 ligand (ZN), 5 pockets (best druggability 0.59). MolNFT v1 #126881 on GenesisL1…
- PDB
- 5MG7
- Type
- protein + DNA
- Length
- 418 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cellular tumor antigen P53; DNA
- UniProt
- P04637
- Ligands
- ZN
- Pockets
- 5 · best druggability 0.59
Structure
x-ray diffraction · 2 distinct chains · 12% helix, 34% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Cellular tumor antigen P53 | protein | 199 | 12% helix, 34% strand | P04637 |
| C | DNA | dna | 20 | — | — |
Ligands and binding sites
- ZN · Zinc ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 383 | 0.59 | 0.76 | 35 | empty |
| 2 | 114 | 0.39 | 0.75 | 22 | empty |
| 3 | 107 | 0.37 | 0.74 | 23 | empty |
| 4 | 74 | 0.34 | 0.76 | 17 | empty |
| 5 | 72 | 0.30 | 0.74 | 18 | empty |
Interfaces
3 interfaces between chains.
- A–B · 516 Ų buried · 8 hydrogen bonds · protein-protein
- A–C · 243 Ų buried · 8 hydrogen bonds · protein-nucleic
- B–C · 239 Ų buried · 6 hydrogen bonds · protein-nucleic
Compared structures
- 5MG7 · New Insights into the Role of DNA Shape on Its Recognition by p53 Proteins (complex… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P04637
- Elsewhere: RCSB PDB 5MG7 · PDBe 5MG7 · UniProt P04637
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