MolNFT v1 · #126515 · protein

Crystal structure of chaetomium thermophilum BRR2 helicase core in complex with PRP8 JAB1 domain

5M59 · Putative pre-mRNA splicing factor: “Crystal structure of chaetomium thermophilum BRR2 helicase core in complex with PRP8 JAB1 domain”. X-ray diffraction, 20 pockets (best druggability 0.89). MolNFT v1 #126515 on GenesisL1: 3D…

PDB: 5M59
Type: protein
Length: 7,951 residues
Chains: 8
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Putative pre-mRNA splicing factor; Pre-mRNA splicing helicase-like protein
UniProt: G0SFL3, G0S0B9
Pockets: 20 · best druggability 0.89

Structure

x-ray diffraction · 8 distinct chains · 37% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B	Putative pre-mRNA splicing factor	protein	266	23% helix, 26% strand	G0SFL3
A	Pre-mRNA splicing helicase-like protein	protein	1738	41% helix, 16% strand	G0S0B9
D	Putative pre-mRNA splicing factor	protein	263	22% helix, 27% strand	G0SFL3
C	Pre-mRNA splicing helicase-like protein	protein	1702	40% helix, 13% strand	G0S0B9
F	Putative pre-mRNA splicing factor	protein	265	23% helix, 27% strand	G0SFL3
E	Pre-mRNA splicing helicase-like protein	protein	1740	39% helix, 16% strand	G0S0B9
H	Putative pre-mRNA splicing factor	protein	267	25% helix, 25% strand	G0SFL3
G	Pre-mRNA splicing helicase-like protein	protein	1710	38% helix, 15% strand	G0S0B9

Ligands and binding sites

ACT · Acetate ion · additive · 4 copies · chains A, C, E, G

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1035	0.89	0.90	102	empty
2	1023	0.89	0.90	117	empty
3	803	0.88	0.90	99	empty
4	950	0.87	0.88	91	empty
5	1157	0.85	0.86	91	empty

Interfaces

10 interfaces between chains.

B–A · 2616 Å² buried · 38 hydrogen bonds · protein-protein
H–G · 2615 Å² buried · 33 hydrogen bonds · protein-protein
D–C · 2593 Å² buried · 32 hydrogen bonds · protein-protein
F–E · 2563 Å² buried · 31 hydrogen bonds · protein-protein
F–G · 547 Å² buried · 3 hydrogen bonds · protein-protein

Compared structures

5M59 · Crystal structure of Chaetomium thermophilum Brr2 helicase core in complex with Prp8 Jab1… · the same entry in another collection · chain B against B, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt G0SFL3
Every structure of UniProt G0S0B9
Elsewhere: RCSB PDB 5M59 · PDBe 5M59 · UniProt G0SFL3 · UniProt G0S0B9

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