MolNFT v1 · #126250 · protein

Cys-gly dipeptidase glij mutant D38H

5LX4: “Cys-gly dipeptidase glij mutant D38H”. X-ray diffraction, 1 ligand (FE), 3 pockets (best druggability 0.36). MolNFT v1 #126250 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5LX4
Type: protein
Length: 381 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Dipeptidase
EC: 3.4.13.19
UniProt: Q4WMJ8
Ligands: FE
Pockets: 3 · best druggability 0.36

Structure

x-ray diffraction · 1 distinct chain · 51% helix, 12% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Dipeptidase (EC 3.4.13.19)	protein	381	51% helix, 12% strand	Q4WMJ8

Ligands and binding sites

FE · Fe (III) ion · metal · chains A
GOL · Glycerol · additive · 4 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	110	0.36	0.73	15	empty
2	63	0.34	0.77	13	empty
3	73	0.31	0.73	19	FE

Compared structures

5LX4 · Cys-Gly dipeptidase GliJ mutant D38H · the same entry in another collection · chain A against A, TM-score 1.00
Q4WMJ8 · AlphaFold monomer V2.0 prediction for dipeptidase glij (Q4WMJ8) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q4WMJ8
Elsewhere: RCSB PDB 5LX4 · PDBe 5LX4 · UniProt Q4WMJ8

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