MolNFT v1 · #126248 · protein
Lt 14-3-3 in complex with PI4KIIIB peptide
5LX2 · KLTH0G14146P: “Lt 14-3-3 in complex with PI4KIIIB peptide”. X-ray diffraction, 2 pockets (best druggability 0.46). MolNFT v1 #126248 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5LX2
- Type
- protein
- Length
- 241 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- KLTH0G14146P; Phosphatidylinositol 4-kinase beta
- UniProt
- C5DN49, A0A0B4J1S8
- Pockets
- 2 · best druggability 0.46
Structure
x-ray diffraction · 2 distinct chains · 83% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | KLTH0G14146P | protein | 235 | 85% helix, 0% strand | C5DN49 |
| B | Phosphatidylinositol 4-kinase beta | protein | 6 | 0% helix, 0% strand | A0A0B4J1S8 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 87 | 0.46 | 0.80 | 17 | empty |
| 2 | 69 | 0.34 | 0.76 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 536 Ų buried · 12 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 modified (phosphorylation).
Compared structures
- 5LX2 · Lt 14-3-3 in complex with PI4KIIIB peptide · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt C5DN49
- Every structure of UniProt A0A0B4J1S8
- Elsewhere: RCSB PDB 5LX2 · PDBe 5LX2 · UniProt C5DN49 · UniProt A0A0B4J1S8
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