UniProt A0A0B4J1S8
Phosphatidylinositol 4-kinase beta (A0A0B4J1S8)
Phosphatidylinositol 4-kinase beta (UniProt A0A0B4J1S8), EC 2.7.1.67: 7 experimental structures on GenesisL1, 4 ligands bound, 13 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- A0A0B4J1S8
- Protein
- Phosphatidylinositol 4-kinase beta
- EC
- 2.7.1.67
- Experimental structures
- 7
- Predicted models
- 0
- Ligands
- 4
- Pockets
- 13 · 3 records with a druggable one
Structures
7 records of A0A0B4J1S8 in the MolNFT archive: 7 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2N73 | Solution structure of the ACBD3:PI4KB complex | solution nmr | B | — | — |
| 2N73 | Solution structure of the ACBD3:PI4KB complex | solution nmr | B | — | — |
| 5LX2 | Lt 14-3-3 in complex with PI4KIIIB peptide | x-ray diffraction | B | — | 1 (best 0.34) |
| 5LX2 | Lt 14-3-3 in complex with PI4KIIIB peptide | x-ray diffraction | B | — | — |
| 8Q6F | Human PI4KIIIB in complex with covalently bound inhibitor (compound 4) | x-ray diffraction | A | KHR, MG | 4 (best 0.71) |
| 8Q6G | Human PI4KIIIB in complex with covalently bound inhibitor (compound 8) | x-ray diffraction | A | KIH, MG | 5 (best 0.61) |
| 8Q6H | Human PI4KIIIB in complex with covalently bound inhibitor (compound 11) | x-ray diffraction | A | MG, KI7 | 3 (best 0.60) |
Ligands
- MG · Magnesium ion · in 3 records
- KHR · 3-(3-fluorosulfonyloxy-4-methoxy-phenyl)-2,5-dimethyl-7-(pyridin-4-ylmethylamino)pyrazolo[1,5-a]pyrimidine · in 1 record
- KI7 · 3-(3-fluorosulfonyloxy-4-methoxy-phenyl)-7-[(4-fluorosulfonyloxyphenyl)methylamino]-2,5-dimethyl-pyrazolo[1,5-a]pyrimidine · in 1 record
- KIH · 3-(3,4-dimethoxyphenyl)-7-[(4-fluorosulfonyloxyphenyl)methylamino]-2,5-dimethyl-pyrazolo[1,5-a]pyrimidine · in 1 record
Experiment against prediction
- 8Q6H chain A against the predicted model Q9UBF8: TM-score 0.90, RMSD 2.01 Å
- 8Q6F chain A against the predicted model Q9UBF8: TM-score 0.90, RMSD 2.16 Å
- 8Q6G chain A against the predicted model Q9UBF8: TM-score 0.90, RMSD 1.95 Å
Elsewhere
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