MolNFT v1 · #126236 · protein

Ceue (H227L variant) a periplasmic protein from campylobacter jejuni

5LWQ · Enterochelin uptake periplasmic binding protein: “Ceue (H227L variant) a periplasmic protein from campylobacter jejuni”. X-ray diffraction, 2 ligands (NA, BR), 7 pockets (best druggability 0.72). MolNFT v1 #126236 on GenesisL1: 3D…

PDB: 5LWQ
Type: protein
Length: 865 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Enterochelin uptake periplasmic binding protein
UniProt: A0A0W8LI20
Ligands: NA, BR
Pockets: 7 · best druggability 0.72

Structure

x-ray diffraction · 2 distinct chains · 41% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Enterochelin uptake periplasmic binding protein	protein	289	41% helix, 20% strand	A0A0W8LI20
B, C	Enterochelin uptake periplasmic binding protein	protein	288	41% helix, 21% strand	A0A0W8LI20

Ligands and binding sites

NA · Sodium ion · metal · chains C
BR · Bromide ion · ion · 5 copies · chains A, C, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

7 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	507	0.72	0.81	67	NA
2	722	0.68	0.76	76	empty
3	211	0.65	0.84	39	empty
4	502	0.65	0.77	56	empty
5	236	0.64	0.82	37	empty

Interfaces

3 interfaces between chains.

A–C · 542 Å² buried · 5 hydrogen bonds · protein-protein
B–C · 413 Å² buried · 1 hydrogen bond · protein-protein
A–B · 310 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

5LWQ · CeuE (H227L variant) a periplasmic protein from Campylobacter jejuni · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A0W8LI20
Elsewhere: RCSB PDB 5LWQ · PDBe 5LWQ · UniProt A0A0W8LI20

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.