TRNA guanine transglycosylase (tgt) in co-crystallized complex (space group P21) with 6-amino-4-(2-((3AR,4R,6R,6AR)-6-methoxy-2,2- DIMETHYLTETRAHYDROFURO[3,4-D][1,3]DIOXOL-4-YL)ETHYL)-2-(methylamino)- 1H-IMIDAZO[4,5-G]QUINAZOLIN-8(7H)-one

Structure

x-ray diffraction · 2 distinct chains · 45% helix, 18% strand (DSSP).

Ligands and binding sites

• 72C · 4-[2-[(3~{A}~{R},4~{R},6~{R},6~{A}~{R})-4-methoxy-2,2-dimethyl-3~{A},4,6,6~{A}-tetrahydrofuro[3,4-D][1, 3]dioxol-6-yl]ethyl]-6-azanyl-2-(methylamino)-1,7-dihydroimidazo[4,5-g]quinazolin-8-one · ligand · 2 copies · chains A, B
• ZN · Zinc ion · metal · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Interfaces

1 interface between chains.

• A–B · 1539 Ų buried · 10 hydrogen bonds · protein-protein

Compared structures

• 5LPQ · tRNA guanine Transglycosylase (TGT) in co-crystallized complex (space group P21) with… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P28720
• Elsewhere: RCSB PDB 5LPQ · PDBe 5LPQ · UniProt P28720