N-terminal bromodomain of human BRD4 with 5-(5-aminopyridin-3-yl)-8- (((3R,4R)-3-((1,1-dioxidotetrahydro-2H-thiopyran-4-YL)METHOXY) piperidin-4-YL)AMINO)-3-methyl-1,7-naphthyridin-2(1H)-one

Structure

x-ray diffraction · 1 distinct chain.

Ligands and binding sites

• 6XW · 5-(5-aminopyridin-3-yl)-8-(((3R,4R)-3-((1,1-dioxidotetrahydro-2H-thiopyran-4-yl)methoxy)piperidin-4-yl)amino)-3-methyl-1,7-naphthyridin-2(1H)-one · ligand · chains A
• EDO · 1,2-ethanediol · additive · 3 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 5LJ2 · N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH 5-(5-aminopyridin-3-yl)-8-(((3R,4R)-3-((1,1-diox… · the same entry in another collection · chain A against A, TM-score 1.00
• O60885 · AlphaFold monomer V2.0 prediction for bromodomain-containing protein 4 (O60885) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

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• Every structure of UniProt O60885
• Elsewhere: RCSB PDB 5LJ2 · PDBe 5LJ2 · UniProt O60885