GL1X · GenesisL1 explorer

Ligand · 6XW

6XW · 5-(5-aminopyridin-3-yl)-8-(((3R,4R)-3-((1,1-dioxidotetrahydro-2H-thiopyran-4-yl)methoxy)piperidin-4-yl)amino)-3-methyl-1,7-naphthyridin-2(1H)-one

6XW, 5-(5-aminopyridin-3-yl)-8-(((3R,4R)-3-((1,1-dioxidotetrahydro-2H-thiopyran-4-yl)methoxy)piperidin-4-yl)amino)-3-methyl-1,7-naphthyridin-2(1H)-one (C25 H32 N6 O4 S, 512.6 g/mol), in the MolNFT structures on GenesisL1: bound in 2…

Component
6XW
Formula
C25 H32 N6 O4 S
Class
ligand
Structures
2
PDB entries
1

Binding sites

6XW in 2 structures; the first of them:

  • 5LJ2 · N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH 5-(5-aminopyridin-3-yl)-8-(((3R,4R)-3-((1,1-diox… · 6XW A204 · binds TRP81, PRO82, PHE83, GLN85, VAL87, LEU92, LEU94, TYR97 and 5 more
  • 5LJ2 · N-terminal bromodomain of human BRD4 with 5-(5-aminopyridin-3-yl)-8… · 6XW A204 · binds TRP81, PRO82, PHE83, GLN85, VAL87, LEU92, LEU94, TYR97 and 3 more

Residues it binds most

LEU 2, TYR 2, ASN 2, ASP 2, GLN 2, ILE 2, PHE 2, PRO 2, TRP 2, VAL 2 (residue and the binding sites it lines).

Found with

  • EDO · 1,2-ethanediol

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