Myelin-associated glycoprotein (mag) deglycosylated full extracellular domain with co-purified ligand

Structure

x-ray diffraction · 1 distinct chain · 2% helix, 51% strand (DSSP).

Ligands and binding sites

• NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 5 copies · chains A
• FUC · alpha-L-fucopyranose · sugar · chains A
• NGA · 2-acetamido-2-deoxy-beta-D-galactopyranose · sugar
• GAL · beta-D-galactopyranose · sugar · chains A
• SIA · N-acetyl-alpha-neuraminic acid · sugar · chains A
• MAN · alpha-D-mannopyranose · sugar · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Modifications

Observed in the structure: 7 disulfide, 6 glycan (disulfide, N-glycosylation, C-mannosylation).

Compared structures

• 5LF5 · Myelin-associated glycoprotein (MAG) deglycosylated full extracellular domain with… · the same entry in another collection · chain A against A, TM-score 1.00
• P20917 · AlphaFold monomer V2.0 prediction for myelin-associated glycoprotein (P20917) · a predicted model of the same protein · chain A against A, TM-score 0.93

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P20917
• Elsewhere: RCSB PDB 5LF5 · PDBe 5LF5 · UniProt P20917