MolNFT v1 · #125564 · protein
In-gel activity-based protein profiling of a clickable covalent ERK 1/2 inhibitor
5LCJ: “In-gel activity-based protein profiling of a clickable covalent ERK 1/2 inhibitor”. X-ray diffraction, 2 ligands (6TS, SO4). MolNFT v1 #125564 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5LCJ
- Type
- protein
- Length
- 346 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P28482
- Ligands
- 6TS, SO4
Structure
x-ray diffraction · 1 distinct chain.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 346 | — | P28482 |
Ligands and binding sites
- 6TS · [(1~{R},4~{Z})-cyclooct-4-en-1-yl] ~{N}-[4-[4-[[5-chloranyl-4-[[2-(propanoylamino) phenyl]amino]pyrimidin-2-yl]amino]pyridin-2-yl]but-3-ynyl]carbamate · ligand · chains A
- SO4 · Sulfate ion · ion · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 5LCJ · In-Gel Activity-Based Protein Profiling of a Clickable Covalent Erk 1/2 Inhibitor · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P28482
- Elsewhere: RCSB PDB 5LCJ · PDBe 5LCJ · UniProt P28482
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