MolNFT v1 · #125501 · protein
P53 cancer mutant Y220C with CYS182 alkylation
5LAP · Cellular tumor antigen P53: “P53 cancer mutant Y220C with CYS182 alkylation”. X-ray diffraction, 2 ligands (6SM, ZN), 3 pockets (best druggability 0.66). MolNFT v1 #125501 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 5LAP
- Type
- protein
- Length
- 391 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cellular tumor antigen P53
- UniProt
- P04637
- Ligands
- 6SM, ZN
- Pockets
- 3 · best druggability 0.66
Structure
x-ray diffraction · 2 distinct chains · 8% helix, 33% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cellular tumor antigen P53 | protein | 195 | 9% helix, 33% strand | P04637 |
| B | Cellular tumor antigen P53 | protein | 196 | 8% helix, 33% strand | P04637 |
Ligands and binding sites
- 6SM · 5-chloranylpyrimidine-4-carboxylic acid · ligand · 2 copies · chains A, B
- ZN · Zinc ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 507 | 0.66 | 0.78 | 53 | empty |
| 2 | 144 | 0.44 | 0.76 | 20 | empty |
| 3 | 119 | 0.39 | 0.75 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 329 Ų buried · 2 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 covalent (covalent ligand).
Compared structures
- 5LAP · p53 cancer mutant Y220C with Cys182 alkylation · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P04637
- Elsewhere: RCSB PDB 5LAP · PDBe 5LAP · UniProt P04637
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.