MolNFT v1 · #12544 · protein
Structure of the wild-type large gamma subunit of initiation factor EIF2 from pyrococcus abyssi complexed with GDP-MG2+
1KK3 · EIF2GAMMA: “Structure of the wild-type large gamma subunit of initiation factor EIF2 from pyrococcus abyssi complexed…”. X-ray diffraction, 3 ligands (GDP, ZN, MG), 6 pockets (best druggability 0.53). MolNFT v1 #12544 on GenesisL1…
- PDB
- 1KK3
- Type
- protein
- Length
- 398 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- EIF2GAMMA
- UniProt
- Q9V1G0
- Ligands
- GDP, ZN, MG
- Pockets
- 6 · best druggability 0.53
Structure
x-ray diffraction · 1 distinct chain · 18% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | EIF2GAMMA | protein | 398 | 18% helix, 41% strand | Q9V1G0 |
Ligands and binding sites
- GDP · Guanosine-5'-diphosphate · ligand · chains A
- ZN · Zinc ion · metal · chains A
- MG · Magnesium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 223 | 0.53 | 0.77 | 33 | empty |
| 2 | 161 | 0.51 | 0.79 | 36 | empty |
| 3 | 75 | 0.39 | 0.78 | 13 | empty |
| 4 | 95 | 0.39 | 0.76 | 21 | empty |
| 5 | 77 | 0.38 | 0.78 | 18 | empty |
Compared structures
- 1KK3 · Structure of the wild-type large gamma subunit of initiation factor eIF2 from Pyrococcus… · the same entry in another collection · chain A against A, TM-score 1.00
- Q9V1G0 · AlphaFold monomer V2.0 prediction for translation initiation factor 2 subunit gamma… · a predicted model of the same protein · chain A against A, TM-score 0.89
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9V1G0
- Elsewhere: RCSB PDB 1KK3 · PDBe 1KK3 · UniProt Q9V1G0
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.