MolNFT v1 · #124936 · protein
HMIRO1 ef hand and cgtpase domains in the GDP-bound state
5KU1 · Mitochondrial rho GTPase 1: “HMIRO1 ef hand and cgtpase domains in the GDP-bound state”. X-ray diffraction, 3 ligands (GDP, MG, CL), 10 pockets (best druggability 0.63). MolNFT v1 #124936 on GenesisL1: 3D structure, binding sites…
- PDB
- 5KU1
- Type
- protein
- Length
- 398 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mitochondrial rho GTPase 1
- EC
- 3.6.5.-
- UniProt
- Q8IXI2
- Ligands
- GDP, MG, CL
- Pockets
- 10 · best druggability 0.63
Structure
x-ray diffraction · 1 distinct chain · 44% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Mitochondrial rho GTPase 1 (EC 3.6.5.-) | protein | 398 | 44% helix, 15% strand | Q8IXI2 |
Ligands and binding sites
- GDP · Guanosine-5'-diphosphate · ligand · chains A
- MG · Magnesium ion · metal · 2 copies · chains A
- CL · Chloride ion · ion · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
10 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 134 | 0.63 | 0.85 | 19 | empty |
| 2 | 209 | 0.51 | 0.76 | 32 | GDP, CL |
| 3 | 60 | 0.49 | 0.85 | 14 | empty |
| 4 | 154 | 0.48 | 0.77 | 29 | empty |
| 5 | 53 | 0.41 | 0.81 | 15 | empty |
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8IXI2
- Elsewhere: RCSB PDB 5KU1 · PDBe 5KU1 · UniProt Q8IXI2
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