MolNFT v1 · #124922 · protein
Crystal structure of pyrococcus horikoshii quinolinate synthase (nada) with bound dihydroxyacetone phosphate (dhap) and FE4S4 cluster
5KTN · Quinolinate synthase a: “Crystal structure of pyrococcus horikoshii quinolinate synthase (nada) with bound dihydroxyacetone phosphate…”. X-ray diffraction, 4 ligands (SF4, 13P, CL), 2 pockets (best druggability 0.78). MolNFT v1…
- PDB
- 5KTN
- Type
- protein
- Length
- 304 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Quinolinate synthase a
- EC
- 2.5.1.72
- UniProt
- O57767
- Ligands
- SF4, 13P, CL, NH4
- Pockets
- 2 · best druggability 0.78
Structure
x-ray diffraction · 1 distinct chain · 44% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Quinolinate synthase a (EC 2.5.1.72) | protein | 304 | 44% helix, 16% strand | O57767 |
Ligands and binding sites
- SF4 · Iron/sulfur cluster · ligand · chains A
- 13P · 1,3-dihydroxyacetonephosphate · ligand · chains A
- CL · Chloride ion · ion · 2 copies · chains A
- NH4 · Ammonium ion · ion · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 114 | 0.78 | 0.97 | 30 | SF4, 13P |
| 2 | 74 | 0.32 | 0.74 | 21 | empty |
Compared structures
- 5KTN · Crystal structure of Pyrococcus horikoshii quinolinate synthase (NadA) with bound… · the same entry in another collection · chain A against A, TM-score 1.00
- O57767 · AlphaFold monomer V2.0 prediction for quinolinate synthase a (O57767) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O57767
- Elsewhere: RCSB PDB 5KTN · PDBe 5KTN · UniProt O57767
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.