MolNFT v1 · #124815 · protein
Co-crystal structure of lmw-ptp in complex with 2-(benzothiazol-2- ylamino)-2-oxo-1-phenylethanesulfonic acid
5KQG · Low molecular weight phosphotyrosine protein phosphatase: “Co-crystal structure of lmw-ptp in complex with 2-(benzothiazol-2- ylamino)-2-oxo-1-phenylethanesulfonic acid”. X-ray diffraction, 1 ligand (6VX), 1 pocket (best…
- PDB
- 5KQG
- Type
- protein
- Length
- 154 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Low molecular weight phosphotyrosine protein phosphatase
- EC
- 3.1.3.48, 3.1.3.2
- UniProt
- P24666
- Ligands
- 6VX
- Pockets
- 1 · best druggability 0.47
Structure
x-ray diffraction · 1 distinct chain · 44% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Low molecular weight phosphotyrosine protein phosphatase (EC 3.1.3.48, 3.1.3.2) | protein | 154 | 44% helix, 15% strand | P24666 |
Ligands and binding sites
- 6VX · (1~{S})-2-(1,3-benzothiazol-2-ylamino)-2-oxidanylidene-1-phenyl-ethanesulfonic acid · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 82 | 0.47 | 0.82 | 16 | 6VX |
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P24666
- Elsewhere: RCSB PDB 5KQG · PDBe 5KQG · UniProt P24666
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