MolNFT v1 · #124664 · protein

Prototypical P4[R]CNLS

5KLR · Importin subunit alpha-1: “Prototypical P4[R]CNLS”. X-ray diffraction, 1 pocket (best druggability 0.49). MolNFT v1 #124664 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5KLR
Type: protein
Length: 434 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Importin subunit alpha-1; Prototypical P4[R]CNLS
UniProt: P52293
Pockets: 1 · best druggability 0.49

Structure

x-ray diffraction · 2 distinct chains · 73% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B	Importin subunit alpha-1	protein	426	75% helix, 0% strand	P52293
A	Prototypical P4[R]CNLS	protein	8	0% helix, 0% strand	—

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	82	0.49	0.82	13	empty

Interfaces

1 interface between chains.

B–A · 716 Å² buried · 18 hydrogen bonds · protein-protein

Compared structures

5KLR · Prototypical P4[R]cNLS · the same entry in another collection · chain B against B, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P52293
Elsewhere: RCSB PDB 5KLR · PDBe 5KLR · UniProt P52293

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