MolNFT v1 · #124603 · protein
Co-crystal structure of PKA ri alpha cnb-B mutant (G316R/A336T) with cgmp
5KJZ · Camp-dependent protein kinase type I-alpha regulatory…: “Co-crystal structure of PKA ri alpha cnb-B mutant (G316R/A336T) with cgmp”. X-ray diffraction, 1 ligand (PCG), 1 pocket (best druggability 0.66). MolNFT v1 #124603 on…
- PDB
- 5KJZ
- Type
- protein
- Length
- 149 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Camp-dependent protein kinase type I-alpha regulatory subunit
- UniProt
- P10644
- Ligands
- PCG
- Pockets
- 1 · best druggability 0.66
Structure
x-ray diffraction · 1 distinct chain · 34% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Camp-dependent protein kinase type I-alpha regulatory subunit | protein | 149 | 34% helix, 30% strand | P10644 |
Ligands and binding sites
- PCG · Cyclic guanosine monophosphate · ligand · chains A
- GOL · Glycerol · additive · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 160 | 0.66 | 0.86 | 23 | PCG, GOL |
Compared structures
- 5KJZ · Co-crystal structure of PKA RI alpha CNB-B mutant (G316R/A336T) with cGMP · the same entry in another collection · chain A against A, TM-score 1.00
- P10644 · AlphaFold monomer V2.0 prediction for camp-dependent protein kinase type I-alpha… · a predicted model of the same protein · chain A against A, TM-score 0.88
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P10644
- Elsewhere: RCSB PDB 5KJZ · PDBe 5KJZ · UniProt P10644
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