MolNFT v1 · #12457 · protein
Crystal structure analysis of the anthranilate phosphoribosyltransferase from erwinia carotovora at 1.9 resolution (current name, pectobacterium carotovorum)
1KHD: “Crystal structure analysis of the anthranilate phosphoribosyltransferase from erwinia carotovora at 1.9…”. X-ray diffraction, 10 pockets (best druggability 0.76). MolNFT v1 #12457 on GenesisL1: 3D structure, binding sites and…
- PDB
- 1KHD
- Type
- protein
- Length
- 1,301 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Anthranilate phosphoribosyltransferase
- EC
- 2.4.2.18
- UniProt
- Q8VP84
- Pockets
- 10 · best druggability 0.76
Structure
x-ray diffraction · 4 distinct chains · 52% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Anthranilate phosphoribosyltransferase (EC 2.4.2.18) | protein | 324 | 52% helix, 14% strand | Q8VP84 |
| B | Anthranilate phosphoribosyltransferase (EC 2.4.2.18) | protein | 328 | 52% helix, 14% strand | Q8VP84 |
| C | Anthranilate phosphoribosyltransferase (EC 2.4.2.18) | protein | 320 | 53% helix, 13% strand | Q8VP84 |
| D | Anthranilate phosphoribosyltransferase (EC 2.4.2.18) | protein | 329 | 52% helix, 13% strand | Q8VP84 |
Pockets
10 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 448 | 0.76 | 0.85 | 52 | empty |
| 2 | 442 | 0.70 | 0.81 | 48 | empty |
| 3 | 493 | 0.68 | 0.79 | 59 | empty |
| 4 | 284 | 0.61 | 0.79 | 43 | empty |
| 5 | 106 | 0.42 | 0.77 | 14 | empty |
Interfaces
4 interfaces between chains.
- A–D · 881 Ų buried · 9 hydrogen bonds · protein-protein
- B–C · 860 Ų buried · 6 hydrogen bonds · protein-protein
- A–B · 361 Ų buried · 5 hydrogen bonds · protein-protein
- C–D · 62 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 1KHD · Crystal Structure Analysis of the anthranilate phosphoribosyltransferase from Erwinia… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8VP84
- Elsewhere: RCSB PDB 1KHD · PDBe 1KHD · UniProt Q8VP84
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