Research workbench
Crystal structure analysis of the anthranilate phosphoribosyltransferase from erwinia carotovora at 1.9 resolution (current name, pectobacterium carotovorum)
Analyse Crystal structure analysis of the anthranilate phosphoribosyltransferase from… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1KHD
- Type
- protein
- Length
- 1,301 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Anthranilate phosphoribosyltransferase
- EC
- 2.4.2.18
- UniProt
- Q8VP84
- Pockets
- 10 · best druggability 0.76
Structure
x-ray diffraction · 4 distinct chains · 52% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Anthranilate phosphoribosyltransferase (EC 2.4.2.18) | protein | 324 | 52% helix, 14% strand | Q8VP84 |
| B | Anthranilate phosphoribosyltransferase (EC 2.4.2.18) | protein | 328 | 52% helix, 14% strand | Q8VP84 |
| C | Anthranilate phosphoribosyltransferase (EC 2.4.2.18) | protein | 320 | 53% helix, 13% strand | Q8VP84 |
| D | Anthranilate phosphoribosyltransferase (EC 2.4.2.18) | protein | 329 | 52% helix, 13% strand | Q8VP84 |
Pockets
10 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 448 | 0.76 | 0.85 | 52 | empty |
| 2 | 442 | 0.70 | 0.81 | 48 | empty |
| 3 | 493 | 0.68 | 0.79 | 59 | empty |
| 4 | 284 | 0.61 | 0.79 | 43 | empty |
| 5 | 106 | 0.42 | 0.77 | 14 | empty |
Interfaces
4 interfaces between chains.
- A–D · 881 Ų buried · 9 hydrogen bonds · protein-protein
- B–C · 860 Ų buried · 6 hydrogen bonds · protein-protein
- A–B · 361 Ų buried · 5 hydrogen bonds · protein-protein
- C–D · 62 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 1KHD · Crystal Structure Analysis of the anthranilate phosphoribosyltransferase from Erwinia… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8VP84
- Elsewhere: RCSB PDB 1KHD · PDBe 1KHD · UniProt Q8VP84
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