MolNFT v1 · #124472 · protein
Rigor myosin X co-complexed with an actin filament
5KG8 · Unconventional myosin-X: “Rigor myosin X co-complexed with an actin filament”. Electron microscopy, 15 pockets (best druggability 0.60). MolNFT v1 #124472 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5KG8
- Type
- protein
- Length
- 1,616 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Unconventional myosin-X; Actin, alpha skeletal muscle
- UniProt
- Q9HD67, P68135
- Pockets
- 15 · best druggability 0.60
Structure
electron microscopy · 2 distinct chains · 40% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Unconventional myosin-X | protein | 677 | 45% helix, 17% strand | Q9HD67 |
| B, C, D | Actin, alpha skeletal muscle | protein | 313 | 28% helix, 16% strand | P68135 |
Pockets
15 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 443 | 0.60 | 0.76 | 77 | empty |
| 2 | 408 | 0.59 | 0.76 | 84 | empty |
| 3 | 390 | 0.58 | 0.76 | 57 | empty |
| 4 | 327 | 0.57 | 0.77 | 52 | empty |
| 5 | 327 | 0.56 | 0.76 | 69 | empty |
Interfaces
5 interfaces between chains.
- A–B · 138 Ų buried · 1 hydrogen bond · protein-protein
- B–C · 117 Ų buried · 0 hydrogen bonds · protein-protein
- A–C · 80 Ų buried · 1 hydrogen bond · protein-protein
- C–D · 25 Ų buried · 0 hydrogen bonds · protein-protein
- B–D · 15 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 5KG8 · Rigor myosin X co-complexed with an actin filament · the same entry in another collection · chain D against D, TM-score 1.00
- P68135 · AlphaFold monomer V2.0 prediction for actin, alpha skeletal muscle (P68135) · a predicted model of the same protein · chain B against A, TM-score 0.93
- Q9HD67 · AlphaFold monomer V2.0 prediction for unconventional myosin-X (Q9HD67) · a predicted model of the same protein · chain A against A, TM-score 0.82
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9HD67
- Every structure of UniProt P68135
- Elsewhere: RCSB PDB 5KG8 · PDBe 5KG8 · UniProt Q9HD67 · UniProt P68135
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