MolNFT v1 · #12424 · protein
Immune receptor
1KGC · T-cell receptor alpha chain: “Immune receptor”. X-ray diffraction, 2 pockets (best druggability 0.73). MolNFT v1 #12424 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1KGC
- Type
- protein
- Length
- 442 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- T-cell receptor alpha chain; T-cell receptor beta chain
- UniProt
- P01848, P01850
- Pockets
- 2 · best druggability 0.73
Structure
x-ray diffraction · 2 distinct chains · 6% helix, 45% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| D | T-cell receptor alpha chain | protein | 201 | 5% helix, 39% strand | P01848 |
| E | T-cell receptor beta chain | protein | 241 | 7% helix, 49% strand | P01850 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1069 | 0.73 | 0.77 | 83 | empty |
| 2 | 71 | 0.44 | 0.81 | 22 | empty |
Interfaces
1 interface between chains.
- D–E · 2115 Ų buried · 25 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 1KGC · Immune Receptor · the same entry in another collection · chain D against D, TM-score 1.00
- P01850 · AlphaFold monomer V2.0 prediction for T cell receptor beta constant 1 (P01850) · a predicted model of the same protein · chain E against A, TM-score 0.53
- P01848 · AlphaFold monomer V2.0 prediction for T cell receptor alpha chain constant (P01848) · a predicted model of the same protein · chain D against A, TM-score 0.42
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01848
- Every structure of UniProt P01850
- Elsewhere: RCSB PDB 1KGC · PDBe 1KGC · UniProt P01848 · UniProt P01850
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