Crystal structure of mouse CARM1 in complex with inhibitor U3

Structure

x-ray diffraction · 4 distinct chains.

Ligands and binding sites

• DXE · 1,2-dimethoxyethane · ligand · 6 copies · chains B, C, D
• 6ZH · [[[(~{E})-3-[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]prop-2-enyl]amino]-azanyl-methylidene]azanium · ligand · 4 copies · chains A, B, C, D
• M2M · 1-methoxy-2-(2-methoxyethoxy)ethane · ligand · chains C
• EDO · 1,2-ethanediol · additive · 14 copies · chains A, B, C, D
• PEG · Di(hydroxyethyl)ether · additive · 5 copies · chains A, C
• PG4 · Tetraethylene glycol · additive · chains A
• PE8 · 3,6,9,12,15,18,21-heptaoxatricosane-1,23-diol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 5K8X · Crystal structure of mouse CARM1 in complex with inhibitor U3 · the same entry in another collection · chain D against D, TM-score 1.00
• Q9WVG6 · AlphaFold monomer V2.0 prediction for histone-arginine methyltransferase CARM1 (Q9WVG6) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q9WVG6
• Elsewhere: RCSB PDB 5K8X · PDBe 5K8X · UniProt Q9WVG6