MolNFT v1 · #124226 · protein
Crystal structure of mouse CARM1 in complex with inhibitor U2
5K8W: “Crystal structure of mouse CARM1 in complex with inhibitor U2”. X-ray diffraction, 2 ligands (DXE, GJV). MolNFT v1 #124226 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5K8W
- Type
- protein
- Length
- 1,373 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- Q9WVG6
- Ligands
- DXE, GJV
Structure
x-ray diffraction · 3 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | — | protein | 344 | — | Q9WVG6 |
| C | — | protein | 343 | — | Q9WVG6 |
| D | — | protein | 342 | — | Q9WVG6 |
Ligands and binding sites
- DXE · 1,2-dimethoxyethane · ligand · 6 copies · chains A, D, C
- GJV · 9-(7-{[amino(iminio)methyl]amino}-5,6,7-trideoxy-beta-D-ribo-heptofuranosyl)-9H-purin-6-amine · ligand · 4 copies · chains A, B, C, D
- EDO · 1,2-ethanediol · additive · 9 copies · chains A, B, C, D
- PEG · Di(hydroxyethyl)ether · additive · 2 copies · chains A, B
- PG4 · Tetraethylene glycol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 5K8W · Crystal structure of mouse CARM1 in complex with inhibitor U2 · the same entry in another collection · chain D against D, TM-score 1.00
- Q9WVG6 · AlphaFold monomer V2.0 prediction for histone-arginine methyltransferase CARM1 (Q9WVG6) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9WVG6
- Elsewhere: RCSB PDB 5K8W · PDBe 5K8W · UniProt Q9WVG6
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