MolNFT v1 · #124087 · protein

M. thermoresistible impdh in complex with imp and compound 6

5K4Z · Inosine-5'-monophosphate DEHYDROGENASE,INOSINE-5'…: “M. thermoresistible impdh in complex with imp and compound 6”. X-ray diffraction, 2 ligands (IMP, 6Q8), 1 pocket (best druggability 0.73). MolNFT v1 #124087 on GenesisL1: 3D…

PDB: 5K4Z
Type: protein
Length: 332 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Inosine-5'-monophosphate DEHYDROGENASE,INOSINE-5'- monophosphate dehydrogenase
EC: 1.1.1.205
UniProt: A0A100XBM0
Ligands: IMP, 6Q8
Pockets: 1 · best druggability 0.73

Structure

x-ray diffraction · 1 distinct chain · 36% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Inosine-5'-monophosphate DEHYDROGENASE,INOSINE-5'- monophosphate dehydrogenase (EC 1.1.1.205)	protein	332	36% helix, 19% strand	A0A100XBM0

Ligands and binding sites

IMP · Inosinic acid · ligand · chains A
6Q8 · ~{N}-(4-fluorophenyl)-4-(2~{H}-indazol-6-ylsulfamoyl)-3,5-dimethyl-1~{H}-pyrrole-2-carboxamide · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	389	0.73	0.84	41	IMP, 6Q8

Compared structures

5K4Z · M. thermoresistible IMPDH in complex with IMP and Compound 6 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A100XBM0
Elsewhere: RCSB PDB 5K4Z · PDBe 5K4Z · UniProt A0A100XBM0

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.