MolNFT v1 · #12385 · protein
Phage display derived variant of human growth hormone complexed with two copies of the extracellular domain of its receptor
1KF9 · Phage display derived variant human growth hormone: “Phage display derived variant of human growth hormone complexed with two copies of the extracellular domain…”. X-ray diffraction, 10 pockets (best druggability 0.75). MolNFT v1…
- PDB
- 1KF9
- Type
- protein
- Length
- 1,063 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Phage display derived variant human growth hormone; Extracellular domain human growth…
- UniProt
- P10912
- Pockets
- 10 · best druggability 0.75
Structure
x-ray diffraction · 6 distinct chains · 21% helix, 34% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Phage display derived variant human growth hormone | protein | 160 | 68% helix, 0% strand | — |
| B | Extracellular domain human growth hormone receptor (1-238) | protein | 193 | 2% helix, 48% strand | P10912 |
| C | Extracellular domain human growth hormone receptor (1-238) | protein | 175 | 0% helix, 46% strand | P10912 |
| D | Phage display derived variant human growth hormone | protein | 158 | 68% helix, 0% strand | — |
| E | Extracellular domain human growth hormone receptor (1-238) | protein | 193 | 2% helix, 48% strand | P10912 |
| F | Extracellular domain human growth hormone receptor (1-238) | protein | 184 | 0% helix, 49% strand | P10912 |
Pockets
10 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1153 | 0.75 | 0.78 | 123 | empty |
| 2 | 597 | 0.64 | 0.75 | 69 | empty |
| 3 | 203 | 0.58 | 0.80 | 27 | empty |
| 4 | 187 | 0.58 | 0.81 | 26 | empty |
| 5 | 180 | 0.56 | 0.81 | 28 | empty |
Interfaces
9 interfaces between chains.
- A–B · 1171 Ų buried · 19 hydrogen bonds · protein-protein
- D–E · 1154 Ų buried · 14 hydrogen bonds · protein-protein
- A–C · 715 Ų buried · 11 hydrogen bonds · protein-protein
- D–F · 667 Ų buried · 10 hydrogen bonds · protein-protein
- B–C · 494 Ų buried · 10 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 14 disulfide (disulfide).
Compared structures
- 1KF9 · Phage display derived variant of human growth hormone complexed with two copies of the… · the same entry in another collection · chain F against F, TM-score 1.00
- P10912 · AlphaFold monomer V2.0 prediction for growth hormone receptor (P10912) · a predicted model of the same protein · chain B against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P10912
- Elsewhere: RCSB PDB 1KF9 · PDBe 1KF9 · UniProt P10912
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