Efficient targeting of the asialoglycoprotein receptor by polyvalent display of a compact galactosamine mimic

Structure

x-ray diffraction · 2 distinct chains · 16% helix, 28% strand (DSSP).

Ligands and binding sites

• ZPF · N-[(1S,2R,3R,4R,5S)-2,3-dihydroxy-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octan-4-yl]acetamide · ligand · 2 copies · chains A, B
• CA · Calcium ion · metal · 6 copies · chains A, B
• CL · Chloride ion · ion · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

• A–B · 443 Ų buried · 12 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 6 disulfide (disulfide).

Compared structures

• 5JQ1 · Efficient targeting of the asialoglycoprotein receptor by polyvalent display of a compact… · the same entry in another collection · chain A against A, TM-score 1.00
• P07306 · AlphaFold monomer V2.0 prediction for asialoglycoprotein receptor 1 (P07306) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P07306
• Elsewhere: RCSB PDB 5JQ1 · PDBe 5JQ1 · UniProt P07306