MolNFT v1 · #123460 · protein
The crystal structure of FGFR4 kinase domain in complex with LY2874455
5JKG · Fibroblast growth factor receptor 4: “The crystal structure of FGFR4 kinase domain in complex with LY2874455”. X-ray diffraction, 1 ligand (6LF), 2 pockets (best druggability 0.59). MolNFT v1 #123460 on GenesisL1: 3D structure…
- PDB
- 5JKG
- Type
- protein
- Length
- 266 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fibroblast growth factor receptor 4
- EC
- 2.7.10.1
- UniProt
- P22455
- Ligands
- 6LF
- Pockets
- 2 · best druggability 0.59
Structure
x-ray diffraction · 1 distinct chain · 39% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Fibroblast growth factor receptor 4 (EC 2.7.10.1) | protein | 266 | 39% helix, 15% strand | P22455 |
Ligands and binding sites
- 6LF · 2-[4-[E-2-[5-[(1R)-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-1H-indazol-3-yl]ethenyl]pyrazol-1-yl]ethanol · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 286 | 0.59 | 0.78 | 35 | 6LF |
| 2 | 55 | 0.31 | 0.76 | 17 | empty |
Compared structures
- 5JKG · The crystal structure of FGFR4 kinase domain in complex with LY2874455 · the same entry in another collection · chain A against A, TM-score 1.00
- P22455 · AlphaFold monomer V2.0 prediction for fibroblast growth factor receptor 4 (P22455) · a predicted model of the same protein · chain A against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P22455
- Elsewhere: RCSB PDB 5JKG · PDBe 5JKG · UniProt P22455
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