Crystal structure of the GLUA2 lbd in complex with fw

Structure

x-ray diffraction · 1 distinct chain · 37% helix, 20% strand (DSSP).

Ligands and binding sites

• ETE · 2-{2-[2-2-(methoxy-ethoxy)-ethoxy]-ethoxy}-ethanol · ligand · 2 copies · chains A
• FWD · 2-amino-3-(5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-propionic acid · ligand · chains A
• TOE · 2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxyl · ligand · chains A
• NA · Sodium ion · metal · chains A
• PO4 · Phosphate ion · ion · 2 copies · chains A
• PEG · Di(hydroxyethyl)ether · additive · 3 copies · chains A
• PG4 · Tetraethylene glycol · additive · 2 copies · chains A
• PG0 · 2-(2-methoxyethoxy)ethanol · additive · chains A
• EDO · 1,2-ethanediol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

• 5JEI · Crystal structure of the GluA2 LBD in complex with FW · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P19491
• Elsewhere: RCSB PDB 5JEI · PDBe 5JEI · UniProt P19491