MolNFT v1 · #123074 · protein
Structure of rabbit ryanodine receptor RYR1 open state activated by calcium ion
5J8V · Ryanodine receptor 1: “Structure of rabbit ryanodine receptor RYR1 open state activated by calcium ion”. Electron microscopy, 20 pockets (best druggability 0.84). MolNFT v1 #123074 on GenesisL1: 3D structure, binding sites and…
- PDB
- 5J8V
- Type
- protein
- Length
- 13,812 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ryanodine receptor 1
- UniProt
- P11716
- Pockets
- 20 · best druggability 0.84
Structure
electron microscopy · 1 distinct chain · 55% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Ryanodine receptor 1 | protein | 3453 | 55% helix, 4% strand | P11716 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 815 | 0.84 | 0.86 | 120 | empty |
| 2 | 1002 | 0.84 | 0.85 | 113 | empty |
| 3 | 952 | 0.84 | 0.85 | 110 | empty |
| 4 | 695 | 0.83 | 0.86 | 103 | empty |
| 5 | 1008 | 0.82 | 0.83 | 135 | empty |
Interfaces
4 interfaces between chains.
- B–C · 1423 Ų buried · 6 hydrogen bonds · protein-protein
- A–D · 1420 Ų buried · 5 hydrogen bonds · protein-protein
- C–D · 1408 Ų buried · 5 hydrogen bonds · protein-protein
- A–B · 1406 Ų buried · 5 hydrogen bonds · protein-protein
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P11716
- Elsewhere: RCSB PDB 5J8V · PDBe 5J8V · UniProt P11716
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