MolNFT v1 · #123042 · protein

Molecular understanding of USP7 substrate recognition and C-terminal activation

5J7T · Ubiquitin carboxyl-terminal hydrolase 7: “Molecular understanding of USP7 substrate recognition and C-terminal activation”. X-ray diffraction, 9 pockets (best druggability 0.58). MolNFT v1 #123042 on GenesisL1: 3D structure, binding…

PDB: 5J7T
Type: protein
Length: 671 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ubiquitin carboxyl-terminal hydrolase 7
EC: 3.4.19.12
UniProt: Q93009
Pockets: 9 · best druggability 0.58

Structure

x-ray diffraction · 1 distinct chain · 27% helix, 28% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Ubiquitin carboxyl-terminal hydrolase 7 (EC 3.4.19.12)	protein	671	27% helix, 28% strand	Q93009

Pockets

9 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	151	0.58	0.83	20	empty
2	138	0.53	0.81	23	empty
3	289	0.50	0.74	33	empty
4	78	0.48	0.82	18	empty
5	103	0.38	0.76	21	empty

Compared structures

5J7T · Molecular Understanding of USP7 Substrate Recognition and C-Terminal Activation · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q93009
Elsewhere: RCSB PDB 5J7T · PDBe 5J7T · UniProt Q93009

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