MolNFT v1 · #122799 · protein
Monomeric human CU,ZN superoxide dismutase, loops IV and VII deleted, apo form, circular permutant P2/3
5J0C · Superoxide dismutase [cu-ZN],SUPEROXIDE dismutase [cu-zn]…: “Monomeric human CU,ZN superoxide dismutase, loops IV and VII deleted, apo form, circular permutant P2/3”. X-ray diffraction, 3 pockets (best druggability 0.52). MolNFT v1…
- PDB
- 5J0C
- Type
- protein
- Length
- 226 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Superoxide dismutase [cu-ZN],SUPEROXIDE dismutase [cu-zn], OXIDOREDUCTASE,SUPEROXIDE…
- EC
- 1.15.1.1
- UniProt
- P00441
- Pockets
- 3 · best druggability 0.52
Structure
x-ray diffraction · 2 distinct chains · 0% helix, 54% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Superoxide dismutase [cu-ZN],SUPEROXIDE dismutase [cu-zn], OXIDOREDUCTASE,SUPEROXIDE dismutase [cu-zn] (EC 1.15.1.1) | protein | 112 | 0% helix, 54% strand | P00441 |
| B | Superoxide dismutase [cu-ZN],SUPEROXIDE dismutase [cu-zn], OXIDOREDUCTASE,SUPEROXIDE dismutase [cu-zn] (EC 1.15.1.1) | protein | 114 | 0% helix, 54% strand | P00441 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 210 | 0.52 | 0.77 | 28 | empty |
| 2 | 120 | 0.41 | 0.76 | 24 | empty |
| 3 | 103 | 0.40 | 0.77 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 539 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 5J0C · Monomeric Human Cu,Zn Superoxide dismutase, loops IV and VII deleted, apo form, circular… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00441
- Elsewhere: RCSB PDB 5J0C · PDBe 5J0C · UniProt P00441
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