MolNFT v1 · #122711 · protein
Structure of human JAK1 FERM/SH2 in complex with IFNLR1/IL10RA chimera
5IXI · Tyrosine-protein kinase JAK1: “Structure of human JAK1 FERM/SH2 in complex with IFNLR1/IL10RA chimera”. X-ray diffraction, 5 pockets (best druggability 0.77). MolNFT v1 #122711 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 5IXI
- Type
- protein
- Length
- 465 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tyrosine-protein kinase JAK1; Chimera protein of interferon lambda receptor 1 and…
- EC
- 2.7.10.2
- UniProt
- P23458, Q8IU57, Q13651
- Pockets
- 5 · best druggability 0.77
Structure
x-ray diffraction · 2 distinct chains · 35% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tyrosine-protein kinase JAK1 (EC 2.7.10.2) | protein | 436 | 36% helix, 24% strand | P23458 |
| B | Chimera protein of interferon lambda receptor 1 and interleukin-10 receptor subunit alpha | protein | 29 | 21% helix, 0% strand | Q8IU57, Q13651 |
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 379 | 0.77 | 0.87 | 59 | empty |
| 2 | 321 | 0.68 | 0.82 | 29 | empty |
| 3 | 216 | 0.47 | 0.74 | 26 | empty |
| 4 | 104 | 0.37 | 0.75 | 18 | empty |
| 5 | 80 | 0.31 | 0.73 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 1180 Ų buried · 16 hydrogen bonds · protein-protein
Compared structures
- 5IXI · Structure of human JAK1 FERM/SH2 in complex with IFNLR1/IL10RA chimera · the same entry in another collection · chain A against A, TM-score 1.00
- Q8IU57 · AlphaFold monomer V2.0 prediction for interferon lambda receptor 1 (Q8IU57) · a predicted model of the same protein · chain B against A, TM-score 0.26
- Q13651 · AlphaFold monomer V2.0 prediction for interleukin-10 receptor subunit alpha (Q13651) · a predicted model of the same protein · chain B against A, TM-score 0.22
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P23458
- Every structure of UniProt Q8IU57
- Every structure of UniProt Q13651
- Elsewhere: RCSB PDB 5IXI · PDBe 5IXI · UniProt P23458 · UniProt Q8IU57 · UniProt Q13651
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