MolNFT v1 · #122621 · protein
Structure of P450 2B4 F202W mutant
5IUT · Cytochrome P450 2B4: “Structure of P450 2B4 F202W mutant”. X-ray diffraction, 2 ligands (HEM, 32M), 4 pockets (best druggability 0.86). MolNFT v1 #122621 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5IUT
- Type
- protein
- Length
- 460 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cytochrome P450 2B4
- EC
- 1.14.14.1
- UniProt
- P00178
- Ligands
- HEM, 32M
- Pockets
- 4 · best druggability 0.86
Structure
x-ray diffraction · 1 distinct chain · 52% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cytochrome P450 2B4 (EC 1.14.14.1) | protein | 460 | 52% helix, 9% strand | P00178 |
Ligands and binding sites
- HEM · Protoporphyrin IX containing Fe · ligand · chains A
- 32M · 3,6,9,12,15,18-hexaoxahexacosan-1-ol · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 869 | 0.86 | 0.88 | 89 | HEM, 32M |
| 2 | 126 | 0.44 | 0.77 | 21 | empty |
| 3 | 82 | 0.36 | 0.76 | 17 | empty |
| 4 | 64 | 0.31 | 0.75 | 15 | empty |
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00178
- Elsewhere: RCSB PDB 5IUT · PDBe 5IUT · UniProt P00178
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.