MolNFT v1 · #122378 · protein
Repoman-PP1G (protein phosphatase 1, gamma isoform) holoenzyme complex
5INB · SERINE/THREONINE-protein phosphatase PP1-gamma catalytic…: “Repoman-PP1G (protein phosphatase 1, gamma isoform) holoenzyme complex”. X-ray diffraction, 1 ligand (NA), 3 pockets (best druggability 0.44). MolNFT v1 #122378 on…
- PDB
- 5INB
- Type
- protein
- Length
- 326 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SERINE/THREONINE-protein phosphatase PP1-gamma catalytic subunit; Cell division…
- EC
- 3.1.3.16
- UniProt
- P36873, Q69YH5
- Ligands
- NA
- Pockets
- 3 · best druggability 0.44
Structure
x-ray diffraction · 2 distinct chains · 32% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | SERINE/THREONINE-protein phosphatase PP1-gamma catalytic subunit (EC 3.1.3.16) | protein | 293 | 35% helix, 20% strand | P36873 |
| B | Cell division cycle-associated protein 2 | protein | 33 | 0% helix, 18% strand | Q69YH5 |
Ligands and binding sites
- NA · Sodium ion · metal · chains A
- GOL · Glycerol · additive · 6 copies · chains A
- MLI · Malonate ion · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 129 | 0.44 | 0.77 | 19 | empty |
| 2 | 73 | 0.32 | 0.74 | 18 | MLI |
| 3 | 64 | 0.32 | 0.76 | 14 | GOL |
Interfaces
1 interface between chains.
- A–B · 1379 Ų buried · 20 hydrogen bonds · protein-protein
Compared structures
- 5INB · RepoMan-PP1g (protein phosphatase 1, gamma isoform) holoenzyme complex · the same entry in another collection · chain A against A, TM-score 1.00
- P36873 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein phosphatase PP1-gamma… · a predicted model of the same protein · chain A against A, TM-score 1.00
- Q69YH5 · AlphaFold monomer V2.0 prediction for cell division cycle-associated protein 2 (Q69YH5) · a predicted model of the same protein · chain B against A, TM-score 0.28
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P36873
- Every structure of UniProt Q69YH5
- Elsewhere: RCSB PDB 5INB · PDBe 5INB · UniProt P36873 · UniProt Q69YH5
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